Click the [Right Analog-stick] to activate your "blood" vision.
Click the [Left Analog-stick] to duck.
When you pick up the dual pistols and are fighting a Banshee, Blob, or Dark Mark (Evil Tree), hold down the trigger. You will rapid fire and kill the enemy a lot faster.
Be careful when fighting banshees. If you cut off their arms and they still live, they will fire non-stop energy balls at you.
Shoot them in the head once with a shotgun or twice with just about everything else. Sharpshooters should use a high powered rifle to zoom in close. Aim between the eyes, then fire. Its head will roll off (at least on the ground).
When fighting Reapers (the undead with two scythes or cleavers), it is best to conserve ammunition and melee with the shotgun. The blade on the end of this weapon will kill the Reapers in one hit. Use this tactic when there are at most three reapers in the area. When there is more than one reaper in front of you, backpedal to take them on in a single file line.
When fighting a group of enigmas and there is a Dark Mark (Evil Tree), quickly go for the tree. Destroy it before fighting any enemies. When it is destroyed, it will shoot a shockwave, instantly destroying all enemies in that area.
Final battle opponent
When you defeat Lazaurus, if you choose to break the spell of the west, in the final battle you will fight Tala in her vampire form. If you choose to become the new lord of vampires you will fight your ghost-friend Cassidy, when she is an angel, then kill Tala in the intermission sequence.
Quicker kill on Root Of Evil
Use the Blood Frenzy power on the Root Of Evil to avoid killing all of the troublesome enemies and dying quicker during the "Root Of Evil" encounter.
Silver Bullet: Unlimited and more powerful bullets for a short time.
Fear: Some enigmas will run scared for a short time.
Mystic Armor: Strong armor (possible 0 damage) for a short time.
Vindicator: Shoots a chain of lighting that instantly destroys most small monsters.
Kill one of the following types of opponents and they will drop the corresponding weapon for you to collect.
Fat cowboy zombie in Hangtown: Shotgun
Skeleton sniper: Sniper rifle