Easy strikeouts
Change the pitching type to "Classic". During game play, go to the "Game Options" menu and change all their "Take Strike" settings all the way up and "Take Ball" down. This will give you the easiest way to get a strikeout. Note: This will not stop the batter from swinging. He will still swing occasionally.
Throw your fastball nice and low (either side). After that, throw your change-up right down the middle (do not move the pointer, just pitch). Finally, choose your curve/slider/sinker at the bottom right or the top left corners.
Easy base hits
Put players with a speed rating of A or better (for example, Rafael Furcal, Carl Crawford, Juan Pierre, etc.) in your lineup. When the pitcher throws the ball, bunt it down the third base line and use your speed burst to get to first base. It does not matter if it is a left or right handed hitter; they will be safe 99% of the time. You can use A- players, but your success rate drops to about 90% and you must bunt it perfectly.
Easy wall climbs
First, throw a bad pitch. The batter almost always will put on a slam zone. Press [A] slowly. The batter will most likely hit a home run. When the Right Analog-stick icon appears, click it. If done correctly, the fielder will catch the homerun.
Better fantasy draft picks
To get a better draft pick, keep pressing [Back] to go to the previous screen and press [A]. This will bring you back to the draft screen. Keep doing this until you get a good number.