One hit kills
When playing as either Rebecca or Billy and you get bit by a zombie, move the character opposite of your main character directly behind the one you are controlling to have him or her shoot the zombie in the head and kill it in one hit, while the zombie deals you no damage. Note: You must have pistol equipped to save ammunition for a one bullet kill.
Hint Killing zombies
With the shotgun, aim down to the zombie's leg and blow it away. He will fall. Then, take out the handgun and shoot him one more time.
Dail door number puzzle
Enter "4863" on Disc 2, where the cable car is located.
Brake system puzzle
In order to start the train brakes, you must find the Magnetic Keycard (lying on the train control panel in the front car) and you must choose a character to go through the train. Do not choose Rebecca to go through the train. There are too many zombies for her to handle, and she will die. It does not matter if you killed all the zombies in the train, as more will appear. Once you have reached the caboose, use a healing item if necessary. Activate the control panel by using the Magnetic Keycard on the panel. The game will randomly choose one of three numbers to display, and you must figure out what ten numbers add up to the displayed number. The three random numbers and their solutions are as follows:
36: 3 + 3 + 3 + 3 + 3 + 3 + 3 + 3 + 3 + 9
67: 9 + 9 + 9 + 9 + 9 + 9 + 9 + 9 + 9 + 4
81: 8 + 8 + 8 + 8 + 8 + 8 + 8 + 8 + 8 + 9
After doing this, take control of Rebecca and she will do the same thing (but you do not need the keycard). She also has a set of three random numbers to solve. However, unlike Billy, they will not display your current total. The second control panel's three random numbers and their solutions are as follows:
42: 4 + 4 + 4 + 4 + 4 + 4 + 4 + 4 + 4 + 6
53: 5 + 5 + 5 + 5 + 5 + 5 + 5 + 5 + 5 + 8
67: 7 + 7 + 7 + 7 + 7 + 7 + 7 + 7 + 7 + 4
You have now completed the puzzle.
Animal puzzle
The solution for the animal puzzle is Deer, Wolf, Horse, Lion, Snake, Eagle.
Pause timed puzzles
Try to change to your partner during a timed puzzle. Remain idle at the error message to give yourself more time to study the puzzle.
Piano room
When you get to the piano room, make sure you have both characters with you. Have Billy play piano. A door will open by the bar. Have Rebecca go in and take the battery. The door will close. Have Billy play piano again and the door will open.
Custom handgun
When you are in the draining room in the facility basement, you will find the Duralumin case. You have to enter a code, which is 385. The case will open and you will find handgun parts. Combine these with Billy's handgun for a more efficient handgun.
Safer and faster shotgun reload
To reload the shot gun faster, press [Y] to go to the item screen. Combine the shotgun ammunition with the shotgun. You will be able to attack again without having Billy or Rebecca reload and waste precious time.
Save ammunition on first Leech zombie on the train
After the sequence with the first Leech zombie, just go back downstairs and the intermission sequence will take place again.
Items
In the train there are items. If you do not need them, select them but do not take them. When the train crashes, items will be scattered around the wreck. Those are the items that you selected. The items not selected will disappear. This is very important if playing under the hard difficulty setting.
Avoid Leech Zombie explosion
When you fight the Leech Zombie, its legs will swell up at the end and explode, hurting and often killing you or your partner. There are three ways to avoid this. First, just leave as his legs are swelling but before he explodes. The second is to use a Molotov cocktail on him, which will light him on fire and melt into a puddle of slime and leeches. The third way is to kill him while he is still in "human" form, which is best done with the magnum and has the end effect as the Molotov cocktail.
Run through a door when it is swelling. Make sure that nothing is attacking you or your partner when doing this, Return to the room and there will be no extra leeches will no one hurt.
Resident Evil 2 areas
When you eventually get onto the moving cable car, after Billy is taken over the railing by an ape, go across the ravine and head up the pair of steps. You will enter a big room with a metal floor. This is the same area in Resident Evil 2, where you call up the platform train to head down into the main factory (and where you fight a stronger version of the William Birkin mutations). If you go towards the bottom of the screen and go down the lift and into the back room, you will find a television screen with a picture of a Tyrant. This is the same room where you see Mr. X walking towards the camera before smashing it. If you call up the platform and take it down, you will enter the factory sub-levels and walk into the room where Leon/Claire had to carry Ada/Shelly to the security room.
Leech Hunter mini-game bonuses
Successfully complete the Leech Hunter mini-game with one of the following ranks to unlock the corresponding bonus.
"A" rank: Unlimited ammunition for any weapon
"B" rank: Magnum
"C" rank: Hunting Gun
"D" rank: Handgun
"E" rank: Submachine Gun
Leech Hunter: Extra Submachine gun ammunition
As soon as Leech Hunter starts, grab the first leech you see and run out. This will give you a clip to the machine gun.
Leech Hunter: Determining weapon
There is a way to determine if you will get the submachine gun or the magnum. Look at the two herbs in front of the stairs in front of you at the start of the mini-game. If the colors are blue and green, you will get the magnum. If the colors are green and green, you will get the submachine gun. The submachine gun can do what the magnum can and requires a lot less ammunition. Green and green is highly recommended.
If you want the magnum on the Leech Hunter mini-game, load your game on Disc 1 (only if you have passed the game once and have unlocked the Leech Hunter mini-game), then play the mini-game. You will see a Green Herb and a Blue Herb, indicating that the Magnum is there. If you want the Submachine gun, load your saved file with mini-game on Disc 2 and play the mini-game. You will see two Green Herbs, indicating that the Submachine gun is in the game.